GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs3796352 | 1 | rs11717619 | chr3:53003179 | NT5DC2 | chr3:52558386-52569093:- | -0.15 | -3.44 | 0.000611 | Immune reponse to smallpox (secreted IL-2) |
| BRCA | cis | rs3796352 | 1 | rs11717619 | chr3:53003179 | RFT1 | chr3:53122503-53164470:- | 0.26 | 4.1 | 4.37E-5 | Immune reponse to smallpox (secreted IL-2) |
| BRCA | cis | rs3796352 | 1 | rs11717619 | chr3:53003179 | TMEM110 | chr3:52867139-52931547:- | 0.25 | 4.17 | 3.36E-5 | Immune reponse to smallpox (secreted IL-2) |
| BRCA | cis | rs9858542 | 1 | rs11718165 | chr3:49696797 | AMT | chr3:49454212-49460012:- | 0.12 | 3.9 | 0.000102 | Crohn's disease;Ulcerative colitis |
| BRCA | cis | rs9858542 | 1 | rs11718165 | chr3:49696797 | GMPPB | chr3:49758932-49761384:- | -0.12 | -3.53 | 0.000425 | Crohn's disease;Ulcerative colitis |
| BRCA | cis | rs3796352 | 1 | rs11718834 | chr3:52963668 | NT5DC2 | chr3:52558386-52569093:- | -0.16 | -3.53 | 0.000438 | Immune reponse to smallpox (secreted IL-2) |
| BRCA | cis | rs3796352 | 1 | rs11718834 | chr3:52963668 | RFT1 | chr3:53122503-53164470:- | 0.26 | 3.8 | 0.000155 | Immune reponse to smallpox (secreted IL-2) |
| BRCA | cis | rs3796352 | 1 | rs11718834 | chr3:52963668 | TMEM110 | chr3:52867139-52931547:- | 0.27 | 4.41 | 1.16E-5 | Immune reponse to smallpox (secreted IL-2) |
| BRCA | cis | rs3772130 | 1 | rs11719458 | chr3:121382005 | IQCB1 | chr3:121488610-121553926:- | 0.29 | 7.33 | 4.47E-13 | Cognitive performance |
| BRCA | cis | rs3772130 | 1 | rs11719458 | chr3:121382005 | SLC15A2 | chr3:121613171-121663034:+ | -0.14 | -3.93 | 9.07E-5 | Cognitive performance |
| BRCA | cis | rs7647973 | 1 | rs11719762 | chr3:49409002 | AMT | chr3:49454212-49460012:- | 0.14 | 4.93 | 9.47E-7 | Menarche (age at onset) |
| BRCA | cis | rs7647973 | 1 | rs11719762 | chr3:49409002 | CCDC36 | chr3:49235861-49295537:+ | 0.1 | 3.87 | 0.000115 | Menarche (age at onset) |
| BRCA | cis | rs7647973 | 1 | rs11719762 | chr3:49409002 | NCKIPSD | chr3:48711280-48723334:- | 0.17 | 4.26 | 2.22E-5 | Menarche (age at onset) |
| BRCA | cis | rs7647973 | 1 | rs11719762 | chr3:49409002 | P4HTM | chr3:49027341-49044579:+ | 0.1 | 4.13 | 3.96E-5 | Menarche (age at onset) |
| BRCA | cis | rs7647973 | 1 | rs11719762 | chr3:49409002 | WDR6 | chr3:49044637-49053386:+ | -0.14 | -4.36 | 1.4E-5 | Menarche (age at onset) |